LITTLE KNOWN FACTS ABOUT TRASTUZUMAB J CODE.

The phosphorylated HER3 provides docking sites for p85 subunit of PI3K. The thoroughly activated PI3K complex is generated by binding of p110 subunit of PI3K to p85 which can deliver PIP3 through phosphorylating the PIP2. AKT binds to PIP3 which is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both of those threonine and serin phosph